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Monthly Archives: January 2020

New paper published in Structure

Collaborative work with the Hill lab at University of Basel was just published in Structure!  The Structural Basis for Low Conductance in the Membrane Protein VDAC upon β-NADH Binding and Voltage Gating” used NMR, electrophysiology, and atomistic MD simulations to study the mitochondrial ion channel VDAC.  VDAC is a beta-barrel protein with a much larger and less-sensitive pore than the ligand-gated ion channels we also study.  For channels with very narrow pores, understanding how conduction starts can be tricky, but for VDAC it is harder to understand why conduction ever stops.  Sruthi and Shashank contributed atomistic MD simulations of NMR structures solved by the Hill lab.

Congratulations, all!