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Monthly Archives: November 2019

New paper published in eLife

Collaborative work with the Cheng lab at Washington University-St Louis was just published in eLife!  Direct binding of phosphatidylglycerol at specific sites modulates desensitization of a ligand-gated ion channel” used electrophysiology, mass spectrometry, and coarse-grained simulations.  The work demonstrates quantitatively that the prokaryotic pentameric-ligand gated ion channel ELIC sorts membrane lipids to increase the number of charged-lipid headgroups (particularly phosphatidylglycerol headgroups) in its vicinity.  Liam contributed coarse-grained MD simulations of ELIC in multiple lipid mixtures, with results that corresponded remarkably well to the experimental data.

Congratulations, all!