Brannigan Lab

Home » Uncategorized » New paper in Press at JMBI

New paper in Press at JMBI

Congratulations to Kristen and Liam – their paper Untangling direct and domain-mediated interactions between nicotinic acetylcholine receptors in DHA-rich membranes was accepted to the Journal of Membrane Biology! This paper builds on Liam’s previous results that nAChR boundary lipids are enriched for polyunsaturated acids (PUFAs) in membranes that form domains, like the white lipids in the top row.   Here we tested whether this was still true if the PUFA-rich domains could not form (bottom row), as well as how domain formation affects oligomerization of nAChRs. nAChRs seem to be corralled by the domains, so they dimerize at lower protein concentrations.

figure2


Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

%d bloggers like this: