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New paper in Press at BBA-Biomembranes

The preference of the nicotinic acetylcholine receptor (nachr) for certain lipid environments has been a subject of debate for decades. Liam’s paper “Boundary lipids of the nicotinic acetylcholine receptor: Spontaneous partitioning via coarse-grained molecular dynamics simulation”, which was just accepted at BBA-Biomembranes,  uses coarse-grained molecular dynamics to equilibrate the local lipid environment around an nAChR in a ternary membrane mixture.  We find a high affinity of omega-3 fatty acids (like those found in fish oil) for the nAChR interface with the membrane.  This suggests there could be specific interactions with nAChR that underly the benefits of fish oil for function of the central nervous system.

nAChR Boundary lipids


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