Brannigan Lab

Home » 2018 » July

Monthly Archives: July 2018

New paper on q-bio on nAChR boundary lipids

The preference of the nicotinic acetylcholine receptor (nachr) for certain lipid environments has been a subject of debate for decades.  This new paper under review at BBA-Biomembranes uses coarse-grained molecular dynamics to equilibrate the local lipid environment around an nAChR in a ternary membrane mixture.  We find a high affinity of omega-3 fatty acids (like those found in fish oil) for the nAChR interface with the membrane.  This suggests there could be specific interactions with nAChR that underly the benefits of fish oil for function of the central nervous system.

nAChR Boundary lipids